Al and Ed
Alphonse's relationship with his older brother is easily the strongest and most significant of his personal relationships. Though the Elric brothers have wildly different personalities and argue often about the best way to go about things, they are close enough that each would readily and willingly give his life for the other. Alphonse is particularly supportive of his brother and holds a great deal of faith in him despite the fact that Edward almost constantly requires Al to look after him and keep him from getting into trouble. Edward is, himself, very protective of Al, but Alphonse's care of his brother has been described by Winry as being almost parental. While Ed continues to search feverishly for a way to return his brother to normal, Al refuses to be the only one to benefit and insists that he only wants to regain his human body if Edward can restore his right arm and leg by the same means.